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Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light

NCT05793437 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 84

Last updated 2024-02-01

No results posted yet for this study

Summary

The aim of this study is to conduct a prospective, single-center randomized controlled study to investigate the changes of plasma NFL concentration in patients undergoing laparoscopic surgery with mild hypercapnia, and further explore its impact on the central nervous system.

Conditions

  • Hypercapnia

Interventions

BEHAVIORAL

permissive hypercapnia

Tidal volume (6-8ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:45～55mmHg

BEHAVIORAL

normocapnia

Tidal volume (8-10ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:35～45mmHg

Sponsors & Collaborators

  • Affiliated Hospital of Jiaxing University

    lead OTHER

Principal Investigators

  • Qinghe Zhou · Affiliated Hospital of Jiaxing University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-01
Primary Completion
2024-01-28
Completion
2024-01-28

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05793437 on ClinicalTrials.gov