Midwest TXTXT Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence

Summary

This research study uses a cluster randomized controlled trial design to evaluate the effectiveness of Treatment Text (TXTXT) intervention on adherence and viral load suppression at 3- and 6- months post intervention initiation for youth and young adults with HIV. A total of 12 clinics will be randomized into one of the following two conditions:

1. Comparison Arm (n=6 clinics)- Clinics randomized to the comparison arm will have participants receive the standard of care for 3 months, followed by a 3-month intervention period.
2. Intervention Arm (n=6 clinics)- Clinics randomized to the intervention arm will have participants receive the TXTXT intervention for 6 months.

Conditions

• HIV Infections

Interventions

BEHAVIORAL

Treatment Text (TXTXT)

This study will test a tailored, personalized SMS text message reminder intervention to improve adherence to ART among non-adherent youth and young adults with HIV. Participants will use their own cell phones for receipt of the intervention. Participants will have the option to choose a tailored personalized message that may be changed as requested throughout the 6-month intervention period. Participants will be asked to send a text message response indicating that that have successfully (or not) taken their meds per schedule. No identifying patient information will be included in the SMS text to protect patient confidentiality.

BEHAVIORAL

Standard of Care

Standard of care ART adherence support includes adherence counseling during visits scheduled at least twice annually and appointment reminders.

Sponsors & Collaborators

• University of Illinois at Chicago

  collaborator OTHER

• KC Care Health Center

  collaborator UNKNOWN

• Eskenazi Health

  collaborator OTHER

• Corktown Health Center

  collaborator UNKNOWN

• Howard Brown Health Center

  collaborator OTHER

• University of Cincinnati

  collaborator OTHER

• Indiana University

  collaborator OTHER

• Duke University

  collaborator OTHER

• Amity Medical Group

  collaborator UNKNOWN

• Valley AIDS Council

  collaborator OTHER

• Baylor College of Medicine

  collaborator OTHER

• AIDS Healthcare Foundation

  collaborator OTHER

• Comprehensive Care Center of Southwest Louisiana

  collaborator UNKNOWN

• Ann & Robert H Lurie Children's Hospital of Chicago

  lead OTHER

Principal Investigators

• Amy Johnson, PhD · Ann & Robert H Lurie Children's Hospital of Chicago

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

16 Years

Max Age

35 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-04-17

Primary Completion

2025-08-31

Completion

2025-08-31

Countries

• United States

Study Locations