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Therapeutic Efficacy of Orbital Radiotherapy in Patients With Graves' Orbitopathy

NCT05775185 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 26

Last updated 2023-10-19

No results posted yet for this study

Summary

The purpose of the present interventional study is to assess the changes in the therapeutic response, ocular manifestations of Graves' orbitopathy and quality of life during the first year after orbital radiotherapy. The main questions it aim to answer are:

1. How effective is orbital radiotherapy used as first- or second-line treatment in patients with Graves' orbitopathy?
2. How does the quality of life changes after orbital radiotherapy?

Participants have active moderate-to-severe Graves' orbitopathy and are treated with low dose fractionated orbital radiotherapy for two weeks. During the follow-up period they undergo regular ocular examinations and fill out a disease-specific questionnaire.

Conditions

  • Graves Ophthalmopathy

Interventions

RADIATION

Orbital radiotherapy

Low dose fractionated orbital radiotherapy, total dose 20 Gy in 2-week period.

Sponsors & Collaborators

  • Medical University of Sofia

    lead OTHER

Principal Investigators

  • Mariya A Stoynova · Medical University of Sofia: Medicinski universitet-Sofia

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-25
Primary Completion
2021-02-25
Completion
2021-02-25

Countries

  • Bulgaria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05775185 on ClinicalTrials.gov