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Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury

NCT05746650 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-09-24

No results posted yet for this study

Summary

The study is a 2-week human study where 40 patients who are scheduled to undergo reconstructive knee surgery are randomized to administration of GH or placebo following or without neuromuscular electrical stimulation of hamstring muscles.The overall aim is to determine, the role of muscle connective tissue protein synthesis in muscle injury and repair.

Conditions

  • Muscle Injury

Interventions

PROCEDURE

Electrical stimulation

Experimentally induced muscly injury via. neuromuscular electrical stimulation of the hamstring muscles

DRUG

Growth hormone (somatropin)

Daily injection of growth hormone

OTHER

Control (No electrical stimulation, nor growth hormone)

No electrical stimulation, nor growth hormone

Sponsors & Collaborators

  • Bispebjerg Hospital

    lead OTHER

Principal Investigators

  • Grith Højfeldt, PhD · Institute of Sports Medicine, Bispebjerg Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-24
Primary Completion
2027-06-01
Completion
2027-09-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05746650 on ClinicalTrials.gov