MedTrace Logo

Investigating the Tumour Immune Response of Radiotherapy

NCT05076500 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-06-11

No results posted yet for this study

Summary

This study aims to investigate immune changes which occur before and following standard radiotherapy in a range of tumour types. We will collect tissue and blood samples before and after radiation treatment from participants across six cancer types: cervical, rectal, Head and Neck cancer, nodal non-Hodgkin lymphoma, cutaneous lymphoma and cutaneous squamous cell carcinoma/ basal cell carcinoma.

Conditions

Interventions

PROCEDURE

Biopsy and blood sample collection

A pre-treatment diagnostic biopsy sample plus 1 mandatory biopsy (during/post-radiotherapy \[irradiated site\]) will be collected from each participant. Matched blood samples will be collected from participants at baseline, during/post-radiotherapy, and if radiotherapy continues after the on-treatment biopsy is taken, an additional end of treatment blood sample will be collected.

Sponsors & Collaborators

  • The Christie NHS Foundation Trust

    collaborator OTHER

  • University of Manchester

    lead OTHER

Principal Investigators

  • Timothy M Illidge · University of Manchester

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-14
Primary Completion
2026-07-14
Completion
2026-08-14

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05076500 on ClinicalTrials.gov