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The Effect of Probiotic Lozenges on White Spot Lesion Development in Orthodontic Patients

NCT05738369 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2026-04-09

No results posted yet for this study

Summary

The goal of this randomized clinical trial was to investigate the effect of probiotic lozenges on the development of white spot lesions (WSLs) compared to a positive control, and no treatment.

Conditions

  • White Spot Lesion

Interventions

DIETARY_SUPPLEMENT

Biogaia L. reuteri Prodentis® lozenges

Participants were instructed to use the lozenges twice daily after brushing their teeth; once in the morning and once in the evening

DIETARY_SUPPLEMENT

Hersheyland Ice Breakers Mints sugar free lozenges

Hersheyland Ice Breakers Mints sugar free lozenges

Sponsors & Collaborators

  • Jordan University of Science and Technology

    lead OTHER

Principal Investigators

  • Susan Al-Khateeb · Faculty of Dentistry/Jordan University of Science and Technology

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
17 Years
Max Age
33 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-02-14
Primary Completion
2022-07-01
Completion
2022-12-01

Countries

  • Jordan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05738369 on ClinicalTrials.gov