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Trained and Heterologous Induced-immune Responses to Tropical Infectious Diseases

NCT05722054 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2023-02-10

No results posted yet for this study

Summary

Validation of ex vivo immune assays that are surrogates of complex in vitro assays and animal models studies to identify the occurrence, strength, and kinetics of trained and heterologous immunity may significantly impact public health. In this study, the investigators translate findings from systems biology approaches into contextualized in vitro and ex vivo assays in children living in settings where tropical infectious diseases are highly prevalent. The investigators first reproduce the Vitro assays using culture of monocytes, co-culture of T cells and dendritic cells. Based on data from contextualized assays, the investigators will select, test, and validate candidates' surrogate markers of trained immunity and heterologous immunity.

The TSH-IMMO is a prospective cohort study. Participants aged 1 to 12 years and living in Lambaréné, Gabon, will be recruited.

Conditions

  • Tropical Infectious Disease

Interventions

OTHER

Diagnostic tests

Blood smears; rapid diagnostic tests; complete blood counts with differential; "leucoconcentration"; urine examination; nasal/throat swabs, stool examination.

OTHER

Equilibrate diet

Nutritionally-balanced Alimentation

Sponsors & Collaborators

  • Centre de Recherche Médicale de Lambaréné

    lead OTHER

Eligibility

Min Age
1 Year
Max Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-31
Primary Completion
2024-06-30
Completion
2024-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05722054 on ClinicalTrials.gov