Genetic Evaluation and Modification of Lifestyles to Improve Female Life Expectancy

Summary

The GEMLIFE Study is a 12-month clinical trial for menopausal women. The purpose of this study is to promote an improved aging process for women in menopause through lifestyle changes. The changes will include a heart healthy diet, structured walking program, and mindfulness-based stress reduction. During the study, the investigators will monitor components of your genetic make-up that will tell us how you are aging. Investigators will also monitor bloodwork for inflammation that can affect medical conditions. Study participants may qualify if you are within 5 years of your last menstrual period and have well controlled medical conditions. There is no cost to participants to enroll in the study- only potential benefits to the participant's health and aging process.

Conditions

• Menopause Syndrome
• Inflammation
• Inflammatory Response
• Aging
• Menopause
• Telomere Shortening
• Stress Oxidative

Interventions

BEHAVIORAL

Mediterranean diet

12-week structured program for Mediterranean diet.

BEHAVIORAL

AHA walking program

12-week structured AHA walking program.

BEHAVIORAL

Mindfulness-based stress reduction

8-week structured mindfulness-based stress reduction (Cabot).

BEHAVIORAL

Unstructured Mediterranean diet

Unstructured 12-week program with basic outline for Mediterranean diet.

BEHAVIORAL

Unstructured walking program

Unstructured 12-week walking program.

BEHAVIORAL

Unstructured stress reduction

Unstructured program using mobile application for stress reduction.

Sponsors & Collaborators

• Rush University Medical Center

  lead OTHER

Principal Investigators

• Barbara Soltes, MD · Rush University Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

40 Years

Max Age

60 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-06-22

Primary Completion

2021-06-22

Completion

2021-06-22

Countries

• United States

Study Locations