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Rare Embryonal Tumors of the Central Nervous System: International Registry

NCT05711992 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2025-05-08

No results posted yet for this study

Summary

Central nervous system (CNS) tumors are the most common solid malignancies among children. Although some types of CNS tumors like medulloblastomas and low-grade gliomas are widespread and well-studied, there is a huge number of rare diseases that need further research. This international registry aims to establish a large multicenter database of pediatric and young adult patients with rare embryonal tumors of the central nervous system and describe the clinical presentations, diagnostics, treatment regimens, and outcomes. Embryonal tumors with multilayered rosettes (ETMR), FOXR2-activated CNS neuroblastoma, cribriform neuroepithelial tumor, and CNS tumor with BCOR internal tandem duplication are extremely rare embryonal tumors some of which were first described in the last edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System. Objectives of the registry are 1) to evaluate prognostic factors, 2) to identify diagnostic and treatment gaps, 3) to investigate the characteristics and outcome of the disease with different treatment regimens, and 4) to generate data-based prospective diagnostic and treatment recommendations.

Conditions

  • Embryonal Tumor

Sponsors & Collaborators

  • Immune Oncology Research Institute

    lead OTHER

Principal Investigators

  • Julieta Hoveyan, MD · Immune Oncology Research Institute, Yerevan, Armenia

  • Ruzanna Papyan, MD · Immune Oncology Research Institute, Yerevan, Armenia

  • Gevorg Tamamyan, MD, PhD, DSc · Immune Oncology Research Institute, Yerevan, Armenia

Eligibility

Min Age
1 Day
Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2033-02-28
Completion
2033-02-28

Countries

  • Armenia
  • Canada
  • Hungary
  • India
  • Iran
  • Italy
  • Mexico
  • Peru
  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05711992 on ClinicalTrials.gov