A Study of Tirzepatide (LY3298176) in Adults With Type 2 Diabetes Switching From a GLP-1 RA (SURPASS-SWITCH-2)
NCT05706506 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 152
Last updated 2024-12-13
Summary
The main purpose of this study is to investigate the effects of switching from glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy to tirzepatide glucose-dependent insulinotropic polypeptide (GIP) GLP-1 RA agonist in participants with type 2 diabetes (T2D).
Conditions
- Type 2 Diabetes
- Diabetes Mellitus, Type 2
Interventions
- DRUG
-
Administered SC
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) · Eli Lilly and Company
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-03-08
- Primary Completion
- 2023-10-31
- Completion
- 2023-10-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
A Study of Tirzepatide (LY3298176) in Healthy Participants and Participants With Type 2 Diabetes (T2DM)
NCT02759107 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes
NCT03882970 ·Status: COMPLETED ·Phase: PHASE3
-
Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes
NCT06820281 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone
NCT03954834 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both
NCT05260021 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475 ·Status: RECRUITING ·Phase: PHASE2
-
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
NCT06297603 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study to Investigate the Safety and Tolerability of LY3938577 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
NCT06132126 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of LY3209590 in Participants With Type 2 Diabetes
NCT03367377 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of LY3209590 in Participants With Type 2 Diabetes Mellitus
NCT03736785 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of LY3493269 in Participants With Type 2 Diabetes
NCT04515576 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of Liraglutide Versus Placebo as add-on to Existing Diabetes Medication in Subjects With Type 2 Diabetes and Moderate Renal Impairment
NCT01620489 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Tirzepatide Administered by Two Different Devices in Healthy Participants
NCT04004988 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of LY2599506 (Oral Agent Medication: Glucokinase Activator 1) in Type 2 Diabetes Mellitus
NCT01029795 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase 2 Study of LY3209590 in Participants With Type 2 Diabetes Mellitus
NCT04450394 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of LY3209590 in Participants With Type 1 Diabetes
NCT04450407 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulin
NCT07215312 ·Status: RECRUITING ·Phase: PHASE2
-
A Multiple Dose Study of LY3209590 in Participants With Type 2 Diabetes
NCT06169982 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of a New Type of Insulin in Participants With Type 1 Diabetes on Insulin Injection Therapy
NCT02623452 ·Status: WITHDRAWN ·Phase: PHASE1
-
The Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Therapy
NCT01676116 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of LY3502970 in Participants With Type 2 Diabetes
NCT04426474 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of a New Type of Insulin in Participants With Type 2 Diabetes on Insulin Injection Therapy
NCT02623465 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Study of the Safety and Effectiveness of LY3053102 in Participants With Type 2 Diabetes
NCT02020616 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes
NCT04287179 ·Status: WITHDRAWN ·Phase: PHASE3