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Experimental Pneumococcal Carriage in People Living With HIV

NCT05698225 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2023-01-26

No results posted yet for this study

Summary

The goal of this experimental pneumococcal carriage study is to to characterise rates and determinants of experimental pneumococcal carriage in PLHIV.

The main questions it aims to answer are:

* can PLHIV be experimentally inoculated with pneumococcus in a safe manner?
* what are the immunological determinants of pneumococcal carriage in PLHIV compared to HIV-negative participants?
* how do the pneumococcal carriage dynamics differ between PLHIV and HIV-negative participants?

Participants will be inoculated intranasally with a controlled concentration of pneumococcus after which they will be monitored for 21 days during which nasal and systemic immune dynamics and pneumococcal carriage dynamics will be evaluated. At the end of the study any participants exhibiting carriage will have the pneumococcus cleared with antibiotics.

Conditions

  • Pneumococcus; Pneumonia
  • Hiv

Interventions

OTHER

Streptococcus pneumoniae serotype 6B

A controlled concentration of streptococcus pneumoniae serotype 6B is placed in both nares of participants

Sponsors & Collaborators

  • Liverpool School of Tropical Medicine

    lead OTHER

Principal Investigators

  • Stephen Gordon, MA MD · Malawi-Liverpool Wellcome Centre

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
25 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-31
Primary Completion
2024-01-31
Completion
2024-01-31

Countries

  • Malawi

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05698225 on ClinicalTrials.gov