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Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)

NCT05695495 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2025-04-11

No results posted yet for this study

Summary

N,N-dimethyltryptamine (DMT) is a psychoactive substance with similar effects such as LSD or psilocybin. However, DMT is less well characterized than the latter substances. The present study is a modern randomized cross-over trial, investigating different intravenous DMT boluses over a broad dose range. Thus, different doses will be tested and related to subjective and autonomic effects.

Conditions

  • Healthy

Interventions

DRUG

N,N-Dimethyltryptamine (5mg)

Intravenous bolus application over 45 seconds

DRUG

N,N-Dimethyltryptamine (10mg)

Intravenous bolus application over 45 seconds

DRUG

N,N-Dimethyltryptamine (15mg)

Intravenous bolus application over 45 seconds

DRUG

N,N-Dimethyltryptamine (20mg)

Intravenous bolus application over 45 seconds

DRUG

N,N-Dimethyltryptamine (25mg)

Intravenous bolus application over 45 seconds

DRUG

Placebo (saline)

Intravenous bolus application over 45 seconds

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-06-12
Primary Completion
2025-02-02
Completion
2025-03-04

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05695495 on ClinicalTrials.gov