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Gut Microbiome and Metabolome in Patients With Gallstone Disease After Surgical and Endoscopic Interventions

NCT05689255 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 65

Last updated 2026-04-09

No results posted yet for this study

Summary

The goal of this longitudinal observational cohort study is to examine the changes in the composition and diversity of gut microbiome and systemic metabolome in patients with symptomatic gallbladder stones with or without concomitant common bile duct (CBD) stones who will be undergoing cholecystectomy with or without prior endoscopic sphincterotomy (ERCP-ES) and CBD stones extraction. The main questions it aims to answer are whether there are:

* differences in gut microbiome diversity and composition before and after cholecystectomy
* differences in systemic metabolome before and after cholecystectomy
* gut microbiome and systemic metabolome changes after cholecystectomy

Participants will be asked to provide stool, urine, plasma and saliva samples prior to and 1-6 months after cholecystectomy. For patients with concomitant CBD stones who undergo ERCP-ES before cholecystectomy, bile specimens will be collected from the bile duct during ERCP-ES as well as the gallbladder and/or during cholecystectomy.

Conditions

  • Gallstone Disease
  • Bile Duct Diseases

Sponsors & Collaborators

  • Changi General Hospital

    lead OTHER

Principal Investigators

  • Tiing Leong Ang · Changi General Hospital

Eligibility

Min Age
21 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-23
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05689255 on ClinicalTrials.gov