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Impact of Cardiopulmonary Bypass Flow on Cerebral Autoregulation

NCT05681741 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2023-09-14

No results posted yet for this study

Summary

Cerebral autoregulation is defined by the capacity of the brain to maintain a constant cerebral blood flow (CBF) despite variations of arterial pressure. However, when the arterial pressure is below a critical threshold, cerebral blood decreases.

This critical threshold is called the lower limit of cerebral autoregulation (LLA).

Cardiopulmonary bypass is a unique environment wherein systemic blood flow is totally controlled by the cardiopulmonary bypass pump. High pump flows combined with low arterial pressures has been shown to not compromise neurologic postoperative outcomes.

Our hypothesis is that that LLA may depend on the cardiopulmonary bypass flow, ie the LLA may decrease when the cardiopulmonary bypass flow increases, explaining why low arterial pressure may be well tolerated.

Conditions

  • Cerebral Autoregulation
  • Cardiopulmonary Bypass
  • Mean Arterial Pressure

Interventions

PROCEDURE

current versus high pump flow

during each phase of randomized pump flow, arterial pressure will be increased from 40 to 90 mmHg with vasodilators and/or vasoconstrictors

Sponsors & Collaborators

  • GCS Ramsay Santé pour l'Enseignement et la Recherche

    collaborator OTHER

  • Clinique de la Sauvegarde

    lead OTHER

Principal Investigators

  • Olivier Desebbe, MD · Clinique de la Sauvegarde

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-08
Primary Completion
2023-07-03
Completion
2023-09-12

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05681741 on ClinicalTrials.gov