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Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain

NCT05676827 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2026-02-03

No results posted yet for this study

Summary

The aim of this study is to investigate the relationship of psychological aspects, selected blood parameters, pain, central sensitization, and muscle electromyography activity in patients with chronic masticatory muscle pain.

Conditions

  • TMD
  • Masticatory Muscle Pain

Interventions

DIAGNOSTIC_TEST

Diagnostic Criteria for Temporomandibular Disorders Clinical Examination

Clinical examination made by experienced dentists (minimum 5 years of practice) and trained and calibrated in accordance with the protocol available on the DC/TMD.

DIAGNOSTIC_TEST

Blood test

Blood samples will be tested to investigate two polymorphisms of genes encoding proteins for serotonin receptors HTR2A - rs4941573 in intron 3 and dopamine DRD3 - rs6280 (Ser9Gly) and levels of serotonin, dopamine, Gamma-aminobutyric acid (GABA), Tumor Necrosis Factor α (TNF-α), CGRP, SERT, interleukin 1B, interleukin 6, interleukin 8, interleukin 10 and interleukin 17A.

Sponsors & Collaborators

  • Wroclaw Medical University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05676827 on ClinicalTrials.gov