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lIfestyle iNterventionS for PaIn ReliEf (INSPIRE)

NCT05670314 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 117

Last updated 2025-09-16

Study results available
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Summary

This is a 2x2 factorial design randomised controlled trial in which participants with knee pain will be grouped into the diet intervention, exercise intervention, diet and exercise intervention or placebo arm. The study involves intake of dietary supplements and performing routine exercises which are commonly used and are not pharmacological agents. N= 117. 2x2 intervention with individuals per block: placebo (n=27), diet only (n=26), exercise only (n=40), diet + exercise (n=24)

Conditions

  • Osteoarthritis, Knee

Interventions

DIETARY_SUPPLEMENT

Inulin Fibre supplement

20g/ day. Inulin is easily dissolvable in liquid and can be incorporated into the usual diet - by adding to water, juice, smoothies, cereal, yogurt etc.

DIETARY_SUPPLEMENT

Maltodextrin (Placebo)

10g/ day which can be consumed by adding to breakfast cereal/ smoothie/ yogurt or drink of choice

BEHAVIORAL

Exercise

Joint Academy An app-based exercises platform (Joint Academy®) will be used as an intervention given to the treatment arm. The programme consists of a mixture of open and close chain exercises, a combination of concentric, eccentric and focusing on the global strength of legs including the muscles around the hips and knee joints as well as balance enhancement exercises.

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Ana Valdes, PhD · Professor in Genetic and Molecular Epidemiology

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-05-01
Primary Completion
2025-02-25
Completion
2025-02-25

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05670314 on ClinicalTrials.gov