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Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies

NCT05654766 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2022-12-16

No results posted yet for this study

Summary

The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.

Conditions

Interventions

DIAGNOSTIC_TEST

Flow cytometry

Parameters such as FSC, SSC, median fluorescence of anti CD42b, PAC-1, CD41, CD63, CD62P, as well as Annexin V fluorescence will be assessed.

DIAGNOSTIC_TEST

Platelet aggregation and plasma coagulation

Turbodimetric platelet aggregation test, impedance platelet aggregation test. Standard plasma coagulation test (fibrinogen level, prothrombin test, thrombin time, activated partial thromboplastin time (aPTT)).

Sponsors & Collaborators

  • Belarusian Research Center for Pediatric Oncology, Hematology and Immunology

    collaborator OTHER

  • Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

    lead OTHER_GOV

Principal Investigators

  • [email protected] Shamova, Dr · the Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

  • Viacheslav Dmitriev, Dr · Belarussian Research Center for Pediatric Oncology, Hematology and Immunology

Eligibility

Min Age
1 Year
Max Age
17 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-02
Primary Completion
2024-12-01
Completion
2024-12-31

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05654766 on ClinicalTrials.gov