Prospective Study of Patients With Thrombocytopenia Following HSCT

Summary

Isolated thrombocytopenia is a common and severe complication of HSCT, which often leads to an increased risk of life-threatening hemorrhage, frequent requirement of platelet transfusions and extended hospital stays, representing a challenging clinical problem. Current treatments for thrombocytopenia after HSCT are frequently unsatisfactory in platelet recovery and for preventing potentially fatal bleeding complications. Therefore, it is urgent to explore an effective therapy to improve the outcomes of thrombocytopenia after HSCT. Previous studies have demonstrated that decitabine, a hypomethylating agent, may reduce platelet transfusions in myelodysplastic syndrome (MDS) patients. The investigators conducted an prospective clinical trial to evaluate the safety and efficiency of rhTPO and decitabine in the treatment of thrombocytopenia following HSCT.

Conditions

• Thrombocytopenia
• Hematologic Diseases

Interventions

DRUG

Decitabine

Decitabine

DRUG

rhTPO

rhTPO

OTHER

Conventional Treatment

immunoglobulin, glucocorticoid etc

Sponsors & Collaborators

• Peking University People's Hospital

  collaborator OTHER

• Nanfang Hospital, Southern Medical University

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• Children's Hospital of Soochow University

  collaborator OTHER

• Fujian Medical University Union Hospital

  collaborator OTHER

• Hebei Yanda Ludaopei Hospital

  collaborator OTHER

• The First Affiliated Hospital of Soochow University

  lead OTHER

Principal Investigators

• Depei Wu, PhD,MD · The First Affiliated Hospital of Soochow University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-10-31

Primary Completion

2019-04-12

Completion

2019-04-12

Countries

• China

Study Locations