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Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee

NCT05651997 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-03-12

No results posted yet for this study

Summary

The major objective of this study is to evaluate the efficacy of the MACT versus the AMT for the treatment of large cartilage defects in patellofemoral and femorotibial injuries.

Conditions

  • Articular Cartilage Defect
  • Chondral Defect
  • Osteochondritis

Interventions

PROCEDURE

MACT

* A biopsy of healthy cartilage is taken from a non-weight bearing area of the knee joint during an arthroscopic procedure. * The biopsy is processed in the GMP accredited laboratory to isolate and amplify chondrocytes. * The cells are seeded and cultured on a collagen matrix (Chondro-Gide®, Geistlich Pharma) * The membrane is implanted and sutured onto the injured site.

PROCEDURE

AMT

This treatment combines the microfracture procedure with the application of a bilayer matrix of porcine type I/III collagen (Chondro-Gide, Geistlich Pharma) and the supplementation of autologous bone.

Sponsors & Collaborators

  • Virginie PHILIPPE

    collaborator UNKNOWN

  • Lee Ann LAURENT APPLEGATE

    collaborator UNKNOWN

  • Centre Hospitalier Universitaire Vaudois

    lead OTHER

Principal Investigators

  • Robin MARTIN, MD · CHUV

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
15 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-12-31
Primary Completion
2028-06-01
Completion
2032-06-01

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05651997 on ClinicalTrials.gov