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Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance

NCT05651243 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2024-05-22

No results posted yet for this study

Summary

The goal of this single-blind randomized placebo-controlled trial is to test the effects of an oral ketone supplement on appetite, cognition, metabolism, and cardiovascular function in individuals with obesity and insulin resistance.

The main question\[s\] it aims to answer are:

* Does taking the ketone supplement reduce appetite and improve cognition?
* How does the ketone supplement alter metabolism and cardiovascular function?

Participants will be asked to consume a randomly assigned ketone ester supplement or a placebo and testing will be done to see how the supplement affects the following compared to a placebo:

* appetite,
* cognition,
* metabolism
* cardiovascular function

Researchers will compare individuals with obesity and insulin resistance to individuals with normal weight and no insulin resistance to see if the ketone supplement affects groups differently.

Conditions

  • Metabolic Syndrome

Interventions

DIETARY_SUPPLEMENT

Ketone Ester Supplement

Oral ingestion of a ketone supplement combined with a flavoring agent and diluted in water

OTHER

Placebo

Oral ingestion of cellulose combined with a flavoring agent and diluted in water

Sponsors & Collaborators

  • University of Southern Mississippi

    lead OTHER

Principal Investigators

  • Austin J Graybeal, PhD · University of Southern Mississippi

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-12-28
Primary Completion
2023-12-29
Completion
2023-12-29

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05651243 on ClinicalTrials.gov