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Neonatal Brain Ultrasound With CEUS and Elastography

NCT05648812 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-01-15

No results posted yet for this study

Summary

The aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain perfusion. We use contrast enhanced ultrasound (sulphur hexafluoride) and ultrasound-assisted elastography to evaluate the state of brain perfusion. We will study neonates recruited from the Neonatal Units of Turku University Hospital.

Conditions

  • Neonatal Hypoxic Ischemic Encephalopathy
  • Neonatal Stroke
  • Neonatal Encephalopathy, Unspecified

Interventions

DIAGNOSTIC_TEST

Brain contrast enhanced ultrasound, brain ultrasound elastography

To study brain perfusion with brain ultrasound, contrast enhanced ultrasound of the brain and ultrasound-guided shear-wave elastography

DRUG

Sulfur Hexafluoride

To evaluate the differences in brain perfusion studied by CEUS, comparing different patient groups and babies with no suspected brain pathology

Sponsors & Collaborators

  • Turku University Hospital

    lead OTHER_GOV

Principal Investigators

  • Tiina Laurikainen · Turku University Hospital

  • Riitta Parkkola · Turku University Hospital

  • Vilhelmiina Parikka · Turku University Hospital

  • Jussi Hirvonen · Turku University Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
1 Minute
Max Age
6 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2029-07-31
Completion
2029-12-31

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05648812 on ClinicalTrials.gov