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The Relationship With Mad Honey Containing Grayanotoxin and Ovary Tissue

NCT05643599 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 18

Last updated 2025-01-27

No results posted yet for this study

Summary

For our working group, eighteen healthy Sprague-Dawley female rats were recruited and separated into three groups in an experimental animal laboratory.

Group 1 was given mad honey (n:6) (80 mg/kg); Group 2 was given normal honey (n:6) (80 mg/kg), and Group 3 was the control group (n:6). The groups were given normal and mad honey by oral gavage for 30 days in this study. Rats were anesthetized intramuscularly with 50 mg/kg ketamine and 5 mg/kg xylazine on the 30th day of the study. At the conclusion of the study, female rats in the proestrus phase of the estrous cycle (as indicated by vaginal smear) were sacrificed and their ovarian tissues were placed in neutral formalin solution.

Conditions

  • Ovary Disease

Interventions

DIETARY_SUPPLEMENT

Mad Honey

mad honey (80 mg/kg); (n:6)

DIETARY_SUPPLEMENT

Normal Honey

normal honey (80 mg/kg),(n:6)

DIETARY_SUPPLEMENT

Control

Control

Sponsors & Collaborators

  • Celal Bayar University

    lead OTHER

Principal Investigators

  • Gulsen Gurgen · Manisa Celal Bayar University

  • Suha Turkmen · Karadeniz Teknik University

Eligibility

Min Age
8 Weeks
Max Age
10 Weeks
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-12-01
Primary Completion
2022-12-15
Completion
2022-12-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05643599 on ClinicalTrials.gov