the Effect of Aerobic Training on Insulin Sensitivity on Diabetic Patients During Tobacco Cessation

Summary

* Prevalence of smoking in men and women ages 15 and over who currently smoke any tobacco product on a daily or non-daily basis Egypt smoking rate for 2018 was 21.40%, a 0.1% increase from 2016.
* According to WHO reports, smoking is currently responsible for six million premature deaths every year, of which 600 000 individuals die from the effects of second-hand smoke.
* Egypt is one of the 21 countries and territories of the International Diabetes Federation Middle East and North Africa (MENA) region. 463 million people have diabetes in the world and 55 million people in the MENA Region; by 2045 this will rise to 108 million.
* The most profound impact of smoking in diabetic patients is on insulin sensitivity, Cigarette smoking worsens insulin-resistance in patients with diabetes, as smoking decreases subcutaneous absorption of insulin, resulting in increased dosing requirements. When the action of insulin is impaired chronically in smokers, a dose response relationship can be seen between the number of cigarettes smoked and the degree of insulin resistance. Consequently, quitting smoking should improve glycemic control.
* Therefore diabetic patients can get huge benefits from tobacco cessation as they give their bodies chance to decrease percentage of nicotine and increase percentage of insulin so decrease risk of getting atherosclerosis, so smoking cessation improve glycemic control and insulin sensitivity.

Conditions

• Diabetes

Interventions

BEHAVIORAL

aerobic training , tobacco cessation and nutritional advices

1. Aerobic training program according to Taheri et al 2017: * Mode: recruits large groups of muscles and includes brisk walking on treadmill, cycling, swimming, and jogging * Intensity: submaximal aerobic exercise program (50-60% of maximal heart rate reserve) on treadmill * Frequency: 3 sessions a week for 2 months. * Duration: 60 min/session The training protocol was divided into three phases: the warm up period (10 minutes), the main program (aerobic exercise; 40 minutes), and a cool down period (10 minutes). 2. Tobacco Cessation Programs for 3 months 3. Nutritional advices according to American Diabetes Association (ADA) 2015: for 3 months

BEHAVIORAL

tobacco cessation and nutritional advices

Tobacco Cessation Programs for 3 months Nutritional advices according to American Diabetes Association (ADA) 2015: for 3 months

Sponsors & Collaborators

• Cairo University

  lead OTHER

Principal Investigators

• Nesreen Elnahas, professor · Cairo Univeristy

• Rana elbanaa, lecturer · Cairo Univeristy

• Yasmine mohamed, lectuere · cairo univeristy

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

50 Years

Sex

MALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-11-09

Primary Completion

2023-02-28

Completion

2023-02-28

Countries

• Egypt

Study Locations