Low Particle Emission and Low Noise Tyres

Summary

This study will investigate the biological mechanisms linking sleep disruption by noise and the development of disease. In a laboratory sleep study, the investigators will play synthesised automotive tyre sounds, investigating how acoustical characteristics of tyre noise impact on sleep macrostructure, cardiometabolic profile and cognitive performance (continuous traffic flow or a few individual, but higher level, traffic pass-bys). The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analysed to identify metabolic changes in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which chronic noise exposure at night can lead to the development of diseases in the long term, especially cardiometabolic disorders.

Conditions

• Noise Exposure
• Sleep Disturbance
• Sleep Hygiene
• Metabolic Disturbance
• Cognitive Change

Interventions

RADIATION

Tyre noise - continuous flow

Tyre noise from continuous traffic, throughout the night

RADIATION

Tyre noise - discrete events

Tyre noise from few, discrete traffic events, occurring throughout the night

RADIATION

High noise level

Tyre noise corresponding up to 65 dB LAEq,24h

RADIATION

Moderate noise level

Tyre noise corresponding up to 60 dB LAEq,24h

RADIATION

Low noise level

Tyre noise corresponding up to 55 dB LAEq,24h

RADIATION

Air-filled tyres

Tyre noise from traditional, air-filled tyres

RADIATION

Composite tyres

Tyre noise from newly designed, airless composite tyres

Sponsors & Collaborators

• University of Pennsylvania

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• Swedish National Road and Transport Research Institute

  collaborator UNKNOWN

• Göteborg University

  lead OTHER

Principal Investigators

• Michael G Smith, PhD · Göteborg University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-01-30

Primary Completion

2023-06-16

Completion

2023-12-15

Countries

• Sweden

Study Locations