Modulating Mechanisms in Patients With Chronic Subjective Tinnitus and/or Chronic Pain

Summary

This is a cross-sectional investigation into modulating mechanisms in patients with chronic subjective tinnitus, which will compare 4 patient groups namely chronic tinnitus with chronic pain, chronic tinnitus without chronic pain, chronic pain without tinnitus and healthy controls.

Conditions

• Tinnitus
• Pain

Interventions

DIAGNOSTIC_TEST

Self-reported signs of central sensitization

Self-reported signs of central sensitization by means of the Central Sensitization Inventory (questionnaire)

DIAGNOSTIC_TEST

Objective signs of central sensitization

Objective signs of central sensitization by means of Quantitative Sensory Testing (mechanical and heat detection and pain thresholds, endogenous pain facilitation and inhibition)

DIAGNOSTIC_TEST

Audiological outcome measures (audiometry, tinnitus analysis, uncomfortable loudness) in tinnitus patients with and without pain

* Audiometry Performance of pure tone audiometry according to the modified Hughson-Westlake method * Tinnitus analysis Measurement of psychoacoustic features of tinnitus, including (1) tinnitus pitch, (2) loudness, (3) masking ability, and (4) residual inhibition. * Uncomfortable Loudness measures Performance of Uncomfortable Loudness measurements to evaluate the presence of hyperacusis. .

DIAGNOSTIC_TEST

Cognitive functioning

Evaluation of cognitive functioning by means of: * Auditory Stroop test * Detecting letters task * Letter-number sequencing task

DIAGNOSTIC_TEST

Listening effort

Evaluation of listening effort by means of the modified version of the behavioral listening effort test based on a dual-task paradigm by Degeest, Keppler \& Corthals (2018) .

DIAGNOSTIC_TEST

Self-reported psychological factors

Evaluation of psychological factors by means of: * Depression, Anxiety and Stress Scale (DASS-21) * Beck Depression Inventory (BDI) * Big Five Inventory (BFI) * Connor-Davidson Resilience Scale

DIAGNOSTIC_TEST

Self-reported lifestyle factors

Evaluation of lifestyle factors by means of: Baecke Questionnaire Pittsburg Sleep Quality Index Insomnia Severity Index Stress subscale of the DASS 21

DIAGNOSTIC_TEST

Self-reported measure of pain processing

Evaluation of self-reported pain processing by means of the Pain Catastrophizing Scale

DIAGNOSTIC_TEST

Self-reported quality of life

Self-reported quality of life by means of the SF-36 questionnaire

DIAGNOSTIC_TEST

Self-reported tinnitus severity and impact on daily life

Evaluation of self-reported tinnitus severity and impact on daily life by means of the Tinnitus Functional Index

DIAGNOSTIC_TEST

Self-reported hyperacusis

Evaluation of self-reported characteristics of hyperacusis by means of the Hyperacusis Questionnaire

DIAGNOSTIC_TEST

Self-reported tinnitus characteristics

Evaluation of self-reported tinnitus characteristics by means of the Tinnitus Sample Case History Questionnaire

DIAGNOSTIC_TEST

Self reported neck pain related disability

Evaluation of self-reported neck pain related disability using the Neck Disability Index

Sponsors & Collaborators

• Bijzonder onderzoeksfonds (BOF)

  collaborator UNKNOWN

• University Ghent

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-12-21

Primary Completion

2022-04-01

Completion

2022-04-01

Countries

• Belgium

Study Locations