Gaining Insight Into the Complexity of Pain in Patients With Haemophilia

Summary

Joint pain has been reported as a major problem in people with haemophilia (PwH). Therefore, haemophilia in adults seems clinically more related to a musculoskeletal disorder than a bleeding disorder, with many patients reporting a pain intensity exceeding 6/10 on a visual analogue scale. However, although the complexity of joint pain has been studied in chronic joint pain conditions such as low back pain, osteoarthritis or rheumatoid arthritis, until present only very limited research has been done on joint pain within PwH. Therefore, exploring the underlying mechanisms and the functional implications of this intense joint pain is urgently needed. As such, the main aim of the current prospective observational study is to gain more insights in joint pain in PwH enabling us to move towards adequate pain management in PwH.

Conditions

• Hemophilia A
• Hemophilia B

Interventions

DIAGNOSTIC_TEST

Biopsychological pain assessment

At baseline (T0) patients underwent the somatosensory pain assessment, joint structure and function assessment and filled in all questionnaires. During one month after baseline (T1) patients wore an activity tracker and filled in the Illness Perceptions Questionnaire and the International Physical Activity questionnaire. During one year after the baseline assessment (T2) patients filled in every month The Brief Pain Inventory, Illness Perceptions Questionnaire and the EQ-5D-5L quality of life questionnaire.

Sponsors & Collaborators

• Cliniques universitaires Saint-Luc- Université Catholique de Louvain

  collaborator OTHER

• University Hospital, Antwerp

  collaborator OTHER

• Universiteit Antwerpen

  lead OTHER

Principal Investigators

• Nathalie Roussel · Universiteit Antwerpen

• Cedric Hermans · Cliniques universitaires Saint-Luc / UCLouvain

• Catherine Lambert · Cliniques universitaires Saint-Luc / UCLouvain

• Sébastien Lobet · Cliniques universitaires Saint-Luc / UCLouvain

• Philip Maes · University Hospital, Antwerp

• Anthe Foubert · University of Antwerp - UCLouvain

• Valérie-Anne Chantrain · University of Antwerp - UCLouvain

• Mira Meeus · Universiteit Antwerpen

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2020-02-13

Primary Completion

2023-02-28

Completion

2023-10-13

Countries

• Belgium

Study Locations