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Study of Bevacizumab in Combination With Chemoimmunotherapy and Atezolizumab in Patients With Extensive Stage Small Cell Lung Cancer and Liver Metastases

NCT05588388 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 39

Last updated 2025-11-17

No results posted yet for this study

Summary

This clinical trial aims to assess whether the addition of bevacizumab to atezolizumab and chemotherapy can improve response to treatment and progression-free survival in patients with extensive-stage small cell lung cancer (ES-SCLC) with liver metastases.

The main questions it aims to answer are:

* In patients with ES-SCLC with liver metastases, can bevacizumab in combination with atezolizumab and chemotherapy prolong the length of time that the cancer does not progress?
* Is bevacizumab safe and tolerable when combined with atezolizumab and chemotherapy in patients with ES-SCLC and liver metastases?

The study treatment includes two phases:

* Induction phase: bevacizumab will be administered in combination with atezolizumab and chemotherapy on a 21-day cycle for four cycles.
* Maintenance: atezolizumab and bevacizumab will be administered every 21 days for up to 12 months, or until unacceptable toxicity or disease progression.

Participants will undergo blood tests every 3 weeks and tumor assessments every 6 weeks.

Conditions

  • Extensive-stage Small-cell Lung Cancer
  • Liver Metastases

Interventions

DRUG

Bevacizumab

Addition of Bevacizumab to current standard of care treatment (atezolizumab, carboplatin and etoposide) followed by maintenance Bevacizumab plus Atezolizumab for patients with ES-SCLC with LM

Sponsors & Collaborators

  • Genentech, Inc.

    collaborator INDUSTRY

  • University of Michigan

    collaborator OTHER

  • VA Ann Arbor Healthcare System

    collaborator FED

  • Kamya Sankar

    lead OTHER

Principal Investigators

  • Kamya Sankar, MD · Cedars-Sinai Cancer

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-11
Primary Completion
2026-12-28
Completion
2027-12-28
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05588388 on ClinicalTrials.gov