Phase I/II Trial of Alectinib and Bevacizumab in Patients With Advanced, Anaplastic Lymphoma Kinase (ALK)-Positive, Non-Small Cell Lung Cancer
NCT02521051 · Status: TERMINATED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 11
Last updated 2025-05-13
Summary
This research study is evaluating two drugs, alectinib and bevacizumab, as possible treatments for Advanced Non-Small Cell Lung Cancer (NSCLC).
Conditions
- Non-Small Cell Lung Cancer (NSCLC)
Interventions
- DRUG
-
Alectinib
- DRUG
Sponsors & Collaborators
-
Genentech, Inc.
collaborator INDUSTRY -
Massachusetts General Hospital
lead OTHER
Principal Investigators
-
Justin Gainor, MD · Massachusetts General Hospital
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2015-09-28
- Primary Completion
- 2022-04-30
- Completion
- 2022-04-30
Countries
- United States
Study Locations
More Related Trials
-
A Study of Necitumumab and Abemaciclib in Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT02411591 ·Status: COMPLETED ·Phase: PHASE1
-
Lower Dose Chemotherapy Given More Frequent With Avastin to Treat Advanced Non-Squamous Non-Small Cell Lung Cancer
NCT00655850 ·Status: COMPLETED ·Phase: PHASE2
-
Combination of Erlotinib and Bevacizumab as Second-line Treatment in Patients With Non-small Cell Lung Cancer
NCT00749567 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Gemcitabine-Carboplatin Plus Necitumumab (LY3012211) in Chemotherapy-Naïve Participants With Locally Advanced or Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
NCT02941601 ·Status: WITHDRAWN ·Phase: PHASE2
-
Phase I/II Trial of Bevacizumab, Pemetrexed and Erlotinib in Elderly Patients With Non-Small Cell Lung Cancer
NCT00351039 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Carboplatin, Abraxane, and Bevacizumab in Previously Untreated Patients With Advanced Non-Small Cell Lung Cancer
NCT00642759 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Advanced, Metastatic, or Recurrent Non-Small Cell Lung Cancer
NCT00021060 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Phase I/II Study to Evaluate the Efficacy and Safety of a Combination Chemotherapy
NCT00424840 ·Status: TERMINATED ·Phase: PHASE1
-
A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)
NCT00095225 ·Status: COMPLETED ·Phase: PHASE2
-
Carboplatin, Docetaxel, Bevacizumab, and Erlotinib Versus Chemotherapy Alone in Resected NSCLC
NCT00621049 ·Status: COMPLETED ·Phase: PHASE2
-
Brigatinib and Bevacizumab for the Treatment of ALK-Rearranged Locally Advanced, Metastatic, or Recurrent NSCLC
NCT04227028 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Paclitaxel, Carboplatin, and Bevacizumab With or Without Cixutumumab in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer
NCT00955305 ·Status: TERMINATED ·Phase: PHASE2
-
Evaluation of FKB238 and Avastin in Patients With Advanced/Recurrent Non-squamous Non-small Cell Lung Cancer
NCT02810457 ·Status: COMPLETED ·Phase: PHASE3
-
Paclitaxel + Bevacizumab (Avastin) for the Treatment of Metastatic or Unresectable Angiosarcoma
NCT01055028 ·Status: TERMINATED ·Phase: PHASE2
-
Chemotherapy Combined with ICIs in First-line Alectinib Failed Patients with ALK-rearranged NSCLC
NCT04997382 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Study of Neo-Adjuvant Gemcitabine, Cisplatin and Bevacizumab in Stage IIIA (N2) Non-Squamous Cell Non-Small Cell Lung Cancer
NCT00924209 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Alectinib (CH5424802/RO5424802) in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearranged Non-Small Cell Lung Cancer (NSCLC)
NCT01871805 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Bevacizumab (Avastin®) + Erlotinib as First-line Therapy for Stage IIIB/IV or Recurrent, Non-squamous Cell Lung Cancer
NCT00585377 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to See How Well and How Safely Different Treatments Work in a Group of Participants With Non-Small Cell Lung Cancer (NSCLC)
NCT06624059 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase 2 Trial of Antisense Nucleotide to PKC-Alpha (LY900003, ISIS 3521) Plus Gemcitabine and Carboplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer.
NCT00042679 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Study of Eloxatin and Alimta in Combination With Bevacizumab in Advanced Non-Squamous NSCLC
NCT00251524 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
NCT00054392 ·Status: WITHDRAWN ·Phase: PHASE3
-
Phase II Bevacizumab, Gemcitabine and Carboplatin in Newly Diagnosed Non-Small Cell Lung Cancer
NCT00323869 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Efficacy of Bevacizumab in Combination With Tarceva for Advanced Non-Small Cell Lung Cancer
NCT00130728 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy, Bev, RT, and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer
NCT00280150 ·Status: COMPLETED ·Phase: PHASE1/PHASE2