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Evaluating the Metabolic Effects of Dietary Nitrate Supplementation

NCT05579262 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2023-09-11

No results posted yet for this study

Summary

Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases. In recent years, inorganic nitrate supplementation is clinically emerging as a therapeutic strategy for possible treatment and management of metabolic diseases and cardiometabolic disorders. This is mostly explored in healthy/obese subjects, for improving blood pressure, endothelial function, insulin response and vascular effects. However, the metabolic effects of dietary nitrate for improving skeletal muscle glucose/lipid metabolism, muscle mitochondrial metabolism, muscle blood flow and body fat composition are not comprehensively studied in diabetic/pre-diabetic subjects. Hence, this study aims to evaluate the therapeutic efficacy of a natural nitrate supplement (beetroot juice) for improving overall metabolic health in obese pre-diabetic and non-diabetic subjects.

Conditions

  • Dietary Nitrate Supplementation

Interventions

DIETARY_SUPPLEMENT

Beetroot juice

Single-centre, two-arm study involving 16 weeks of beetroot juice supplementation

Sponsors & Collaborators

  • Institute for Human Development and Potential (IHDP), Singapore

    lead OTHER

Principal Investigators

  • Yaligar Jadegoud, PhD · Institute for Human Development and Potential (IHDP), Singapore

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-08
Primary Completion
2023-04-04
Completion
2023-04-04

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05579262 on ClinicalTrials.gov