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rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction

NCT05575583 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2023-03-08

No results posted yet for this study

Summary

Repetitive transcranial magnetic stimulation (rTMS) is a new neuroelectrophysiological technique developed in recent years. rTMS can affect local and distant cortical function, promote regional reconstruction of cortical function, and has clear curative effect on a variety of neuropsychiatric diseases. Previous study found that rTMS can improve postoperative cognitive function, and there may be a dual biological mechanism. Brain network abnormalities may be the direct cause of postoperative cognitive dysfunction, and neuroinflammation is one of the key molecular mechanisms behind postoperative cognitive dysfunction . rTMS may play a role in the regulation of brain network and inflammatory molecules, and thus play a role in the prevention and treatment of postoperative cognitive dysfunction (POCD).

Conditions

  • Executive Function Disorder
  • Functional Magnetic Resonance Imaging

Interventions

DEVICE

repetitive transcranial magnetic stimulation

The neural navigation system was used to accurately locate the stimulus target.Continuous theta short rapid pulse mode was used. CTBS mode consisted of a slave stimulus delivered every 0.2 seconds (5Hz), and each slave stimulus consisted of three bursts of 50Hz. A single stimulus lasts about 40 seconds and totals 600 pulses.

DEVICE

pseudo repetitive transcranial magnetic stimulation

Participant in control group receive pseudo repetitive transcranial magnetic stimulation

Sponsors & Collaborators

  • The Affiliated Hospital of Xuzhou Medical University

    collaborator OTHER

  • Xuzhou Central Hospital

    lead OTHER

Principal Investigators

  • Yangzi Zhu, Doctor · Xuzhou Central Hospital

  • Liwei Wang, Doctor · Xuzhou Central Hospital

  • Qi Yang, Doctor · Beijing Chao Yang Hospital

  • Daqing Ma · Imperial College London, Chelsea and Westminster Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
45 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-30
Primary Completion
2025-07-30
Completion
2025-09-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05575583 on ClinicalTrials.gov