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Randomized Trial on Same-day SBRT and Surgical Stabilization for Symptomatic Spinal Metastases

NCT05575323 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-05-08

No results posted yet for this study

Summary

The BLEND RCT aims to evaluate the (cost-)effectiveness of same-day SBRT and surgical stabilization with or without decompression for the treatment of symptomatic, unstable spinal metastases on physical functioning four weeks after the start of treatment, compared with the standard of care (surgery followed by radiotherapy as soon as the wound healed sufficiently).

Conditions

  • Spinal Metastases

Interventions

OTHER

Same-day SBRT and spinal surgery

SBRT and surgical stabilization with or without decompression within 24 hours

OTHER

Standard of care

Surgical stabilization with or without decompression followed by cRT or SBRT as soon as the wound is healed sufficiently

Sponsors & Collaborators

  • Radboud University Medical Center

    collaborator OTHER

  • UMC Utrecht

    lead OTHER

Principal Investigators

  • Helena M. Verkooijen, Prof · UMC Utrecht

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-15
Primary Completion
2026-12-31
Completion
2027-06-30

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05575323 on ClinicalTrials.gov