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Comparing Efficacy of Different Drugs Combinations for Serratus Anterior Block for Thoracotomy

NCT05565235 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2022-12-13

No results posted yet for this study

Summary

We aim to compare efficacy and efficiency of serratus anterior block with bupivacaine alone to bupivacaine/magnesium and bupivacaine /nalbuphine in postoperative analgesia for thoracotomy surgery.

Objectives:

To compare bupivacaine alone, bupivacaine/magnesium and bupivacaine /nalbuphine in serratus anterior plane block for intraoperative and postoperative analgesia for thoracotomy surgery.

* The time for 1st rescue analgesia.
* Calculation of the opioid requirements; (the total intra-operative post-operative morphine consumption in first 24h postoperative).
* Assessment of pain score (VAS)- rest, VAS-movement, VAS-cough during post-operative 24hrs period.

Hypothesis:

We hypothesize that magnesium sulfate and nalbuphine can reduce acute postoperative pain and result in efficacious postoperative analgesia due to block of the lateral cutaneous branches of the intercostal nerves (T2 - T6) by diffusion across the inter-fascial planes.

Conditions

  • Post Operative Pain, Acute

Interventions

DRUG

patients will receive intraoperative serratus block with bupivacaine

no additives

DRUG

serratus block with bupivacaine /magnesium

magnesium added

DRUG

serratus block with bupivacaine with nalbuphine

nalbuphine added

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Tamer M. Atteya, M.D · Lecturer of anesthesia,surgical ICU and pain managment

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
16 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-09
Primary Completion
2023-09-10
Completion
2023-11-10

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05565235 on ClinicalTrials.gov