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The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism

NCT05556499 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2022-09-30

No results posted yet for this study

Summary

The PARABONE study aims to investigate the interaction between bone and parathyroid glands in patients with primary hyperparathyroidism (HPT). The study consists of a clinical part aimed at evaluating a series of circulating molecules of bone derivation (osteocalcin, molecules of the WNT pathway, RANKL, osteoprotegerin, Scelrostin, FGF23) in patients with HPT. In particular, the study has as its primary objective to identify the correlation between circulating levels of PTH and levels of GlaOC and GluOC in patients with HPT.

Conditions

  • Hyperparathyroidism, Primary
  • Osteoporosis
  • Parathyroid Neoplasms

Interventions

DIAGNOSTIC_TEST

Biomarker assays

Circulating bone biomarkers assays

Sponsors & Collaborators

  • I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

    lead OTHER

Principal Investigators

  • Sabrina Corbetta, PhD, MD · IRCCS Istituto Ortopedico Galeazzi

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-31
Primary Completion
2026-05-24
Completion
2026-06-24

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05556499 on ClinicalTrials.gov