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Study Evaluating Denosumab on Vascular and Bone Metabolism in Osteoporotic Chronic Kidney Disease (HDENOBS)

NCT05234047 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 21

Last updated 2022-04-14

No results posted yet for this study

Summary

Aim of this study is to evaluate in a population of osteoporotic chronic kidney disease patients the effect of denosumab:

* on coronary artery calcification scores evolution after 24 months of followup
* on abdominal aorta calcification scores evolution after 24 months of followup
* on bone mineral density (femoral T-score) at 24 months
* on bone mineral density evolution (femoral T-score) after 24 months of follow-up
* on bone mineral density evolution (lumbar T-score) after 24 months of follow-up
* on parameters of bone remodelling after 24 months of follow-up
* on cardiovascular morbidity (cardiovascular events) and mortality after 24 months of follow-up
* the tolerance after 24 months of follow-up

Conditions

Interventions

PROCEDURE

MDCT (multidetector computed tomography)

MDCT will be performed at inclusion and after 2 years

PROCEDURE

Dual-energy X-ray absorptiometry

DXA will be performed at inclusion, 1 and 2 years after inclusion

Sponsors & Collaborators

  • University Hospital, Montpellier

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-31
Primary Completion
2025-02-28
Completion
2025-02-28

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05234047 on ClinicalTrials.gov