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CNS Correlates of Extended Sleep Restriction

NCT05547880 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 13

Last updated 2025-05-18

No results posted yet for this study

Summary

Chronic sleep restriction is ubiquitous in both the general population and the military. The deleterious effects of sleep loss on human alertness and cognitive performance have been documented in numerous studies dating back to the nineteenth century. Over the past decade, evidence has emerged indicating that chronic sleep restriction may also precipitate deleterious, long lasting neuropathological changes in the brain. The purpose of this study is to determine neuropathological effects of sleep restriction and identify physiological mechanisms that correlate with sleep loss-induced performance impairment.

Conditions

  • Sleep Restriction

Interventions

DRUG

[11C]ER176

Brain PET with \[11C\]ER176. \[11C\]ER176 is a PET ligand that images TSPO.

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • National Intrepid Center of Excellence

    collaborator FED

  • Walter Reed Army Institute of Research (WRAIR)

    lead FED

Eligibility

Min Age
18 Years
Max Age
39 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-05-23
Primary Completion
2025-03-15
Completion
2025-03-15
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05547880 on ClinicalTrials.gov