MedTrace Logo

Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases

NCT05545007 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 146

Last updated 2026-04-30

No results posted yet for this study

Summary

This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.

Conditions

  • Brain Metastases, Adult

Interventions

RADIATION

Hypofractionated Radiosurgery (HSRS)

HSRS converges multiple radiation beams to deliver a single, large dose of radiation to a discrete tumor target with high precision, thereby minimizing radiation dose to the surrounding normal tissue.

PROCEDURE

Brain metastases surgical resection

Complete surgical resection of brain lesions with adeguate margins.

Sponsors & Collaborators

  • Brainlab AG

    collaborator INDUSTRY

  • Istituto Clinico Humanitas

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-31
Primary Completion
2027-01-31
Completion
2027-01-31

Countries

  • Italy

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05545007 on ClinicalTrials.gov