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Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse

NCT05540561 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 356

Last updated 2026-05-19

No results posted yet for this study

Summary

There is a toxicity linked to the chronic use of nitrous oxide, leading to neurological disorders such as combined sclerosis of the spinal cord. One thus frequently observes patients presenting disorders of walking or paresthesias, of more or less resolving evolution being able to go until the need for using a wheelchair and more recently cases of thrombosis were reported Serum or urine N2O assays are rarely performed routinely, because they do not allow to ensure a real exposure due to the very short half-life of this gas in the body. Thus, other biological monitoring markers are mentioned in the literature, such as vitamin B12 or homocysteine. Unfortunately, there are still no recommendations for biological monitoring of nitrous oxide consumption. Moreover, underlying mechanisms leading to clinical outcomes remains misunderstood.

Conditions

  • Nitrous Oxide Abuse

Interventions

OTHER

blood collection

Biological analyses in the framework of care with conservation of blood samples

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Eligibility

Min Age
14 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-30
Primary Completion
2026-07-30
Completion
2026-07-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05540561 on ClinicalTrials.gov