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Pregabalin Versus Gabapentin Opioid Sparing Effect in Discectomy

NCT05539924 · Status: UNKNOWN · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2022-10-27

No results posted yet for this study

Summary

Pregabalin and gabapentin are both GABA analogue and their mechanism of action is not fully understood. Both drugs when given as a pre-emptive analgesia for spinal surgery were found to reduce intra-and postoperative opioid requirements.

Preoperative intramuscular injection of morphine could reduce the patients' pain during the percutaneous transformational endoscopic discectomy "PTED" surgery and improve the patients' satisfaction without affecting the surgical outcome. The efficacy of adding pregabalin or gabapentin to preoperative intramuscular morphine is not yet investigated.

The current study aims to compare the analgesic effect of both drugs when given preoperatively with intramuscular morphine.

Conditions

  • Opioid Use

Interventions

DRUG

Pregabalin 150mg gabapentin 400mg

oral administration

Sponsors & Collaborators

  • Cairo University

    collaborator OTHER

  • Research Institute of Ophthalmology, Egypt

    lead OTHER

Principal Investigators

  • mohamed s arafa, MD · kasr el aini H

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-15
Primary Completion
2022-11-01
Completion
2022-11-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05539924 on ClinicalTrials.gov