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Povidone-Iodine for Nasal Decolonization

NCT05529173 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 192

Last updated 2024-11-13

Study results available
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Summary

To evaluate the efficacy and tolerability of 10% povidone-iodine in eliminating nasal carriage of Staphylococcus aureus and MRSA. To determine whether a more convenient, single-dose, pre-operative 10% povidone-iodine (PI) application is effective in reducing nasal carriage of S. aureus and MRSA. We expect a statistically significant decrease in S. aureus/MRSA colonization in nasal cultures taken perioperatively after intervention in patients who received pretreatment with PI as compared to patients who received normal saline (NS).

Conditions

  • Surgical Wound Infection
  • Preoperative Care
  • Methicillin-Resistant Staphylococcus Aureus

Interventions

DRUG

Povidone-Iodine 10%

Nasal swab stick application of Povidone-Iodine 10% prior to surgery

DRUG

0.9% NaCl Solution

Nasal swab stick application of 0.9% NaCl Solution prior to surgery

Sponsors & Collaborators

  • Rutgers, The State University of New Jersey

    lead OTHER

Principal Investigators

  • Alex Bekker, MD/PhD · Rutgers University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-06
Primary Completion
2023-11-13
Completion
2023-11-17
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05529173 on ClinicalTrials.gov