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SMILE Trial - Imaging Sub-Study

NCT05528718 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 11

Last updated 2026-03-27

No results posted yet for this study

Summary

This is a pilot sub-study of an ongoing trial comparing N2O to midazolam in MDD and will examine neuroimaging correlates of treatment response.

Conditions

Interventions

DRUG

Nitrous oxide gas for inhalation

This sub-study does not have an intervention and based on the main study the participants who have received N2O will be compared with the midazolam placebo group.

DRUG

Midazolam injection

This sub-study does not have an intervention and based on the main study the participants who have received N2O will be compared with the midazolam placebo group.

Sponsors & Collaborators

  • Unity Health Toronto

    lead OTHER

Principal Investigators

  • Venkat Bhat, MD MSc · Unity Health Toronto

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-07
Primary Completion
2024-03-30
Completion
2024-06-14

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05528718 on ClinicalTrials.gov