Trial Outcomes & Findings for Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit (NCT NCT05521321)
NCT ID: NCT05521321
Last Updated: 2026-07-28
Results Overview
Investigator-originated survey measures (questions) assess lifetime cannabis use. This outcome measure assesses cannabis use.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
658 participants
Primary outcome timeframe
Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-up
Results posted on
2026-07-28
Participant Flow
19 schools were assessed for eligibility. 11 were randomized to intervention or standard of care. Educators were considered to be enrolled only at those schools that received the intervention (they delivered the intervention to the students, and participated in post-intervention qualitative interviews focused on quality assurance and quality improvement).
Unit of analysis: Schools
Participant milestones
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Overall Study
STARTED
|
427 6
|
239 5
|
|
Overall Study
Received Allocated Intervention - Middle School Students
|
134 3
|
144 3
|
|
Overall Study
Received Allocated Intervention - High School Students
|
165 1
|
0 0
|
|
Overall Study
COMPLETED
|
304 4
|
144 3
|
|
Overall Study
NOT COMPLETED
|
123 2
|
95 2
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
Baseline characteristics by cohort
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum (Middle Schools)
n=3 Schools
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum (Middle Schools)
n=3 Schools
Receives another curriculum or no cannabis prevention curriculum
|
Receives the Stanford Cannabis Prevention and Awareness Curriculum (High Schools)
n=1 Schools
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Total
n=7 Schools
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Continuous
|
13.5 years
STANDARD_DEVIATION 0.78 • n=20 Participants
|
13.7 years
STANDARD_DEVIATION 0.47 • n=20 Participants
|
14.8 years
STANDARD_DEVIATION 0.46 • n=40 Participants
|
14.0 years
STANDARD_DEVIATION 0.80 • n=5 Participants
|
|
Sex/Gender, Customized
Woman
|
57 Participants
n=20 Participants
|
59 Participants
n=20 Participants
|
70 Participants
n=40 Participants
|
186 Participants
n=5 Participants
|
|
Sex/Gender, Customized
Man
|
52 Participants
n=20 Participants
|
64 Participants
n=20 Participants
|
78 Participants
n=40 Participants
|
194 Participants
n=5 Participants
|
|
Sex/Gender, Customized
Non-binary/Gender Diverse
|
18 Participants
n=20 Participants
|
13 Participants
n=20 Participants
|
9 Participants
n=40 Participants
|
40 Participants
n=5 Participants
|
|
Sex/Gender, Customized
Unknown/Not Reported
|
1 Participants
n=20 Participants
|
1 Participants
n=20 Participants
|
3 Participants
n=40 Participants
|
5 Participants
n=5 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
36 Participants
n=20 Participants
|
18 Participants
n=20 Participants
|
30 Participants
n=40 Participants
|
84 Participants
n=5 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
88 Participants
n=20 Participants
|
115 Participants
n=20 Participants
|
122 Participants
n=40 Participants
|
325 Participants
n=5 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
4 Participants
n=20 Participants
|
4 Participants
n=20 Participants
|
8 Participants
n=40 Participants
|
16 Participants
n=5 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=20 Participants
|
1 Participants
n=20 Participants
|
0 Participants
n=40 Participants
|
1 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Asian
|
15 Participants
n=20 Participants
|
12 Participants
n=20 Participants
|
24 Participants
n=40 Participants
|
51 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
3 Participants
n=20 Participants
|
1 Participants
n=20 Participants
|
1 Participants
n=40 Participants
|
5 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Black or African American
|
7 Participants
n=20 Participants
|
9 Participants
n=20 Participants
|
3 Participants
n=40 Participants
|
19 Participants
n=5 Participants
|
|
Race (NIH/OMB)
White
|
59 Participants
n=20 Participants
|
69 Participants
n=20 Participants
|
95 Participants
n=40 Participants
|
223 Participants
n=5 Participants
|
|
Race (NIH/OMB)
More than one race
|
28 Participants
n=20 Participants
|
38 Participants
n=20 Participants
|
26 Participants
n=40 Participants
|
92 Participants
n=5 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
16 Participants
n=20 Participants
|
7 Participants
n=20 Participants
|
11 Participants
n=40 Participants
|
34 Participants
n=5 Participants
|
|
Region of Enrollment
United States
|
128 Participants
n=20 Participants
|
137 Participants
n=20 Participants
|
160 Participants
n=40 Participants
|
425 Participants
n=5 Participants
|
PRIMARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assess lifetime cannabis use. This outcome measure assesses cannabis use.
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=127 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=137 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Cannabis Use (Lifetime)
Baseline
|
13 Participants
|
10 Participants
|
|
Cannabis Use (Lifetime)
Post-intervention (approx. 3 days post-baseline)
|
13 Participants
|
13 Participants
|
|
Cannabis Use (Lifetime)
6-month Follow-up
|
15 Participants
|
21 Participants
|
PRIMARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who reported any lifetime cannabis use, received the allocated intervention, and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assess cannabis use in the past 30 days.
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=15 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=21 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Cannabis Use (Past 30 Days)
6-month Follow-up
|
11 Participants
|
11 Participants
|
|
Cannabis Use (Past 30 Days)
Baseline
|
8 Participants
|
3 Participants
|
|
Cannabis Use (Past 30 Days)
Post-intervention (approx. 3 days post-baseline)
|
8 Participants
|
4 Participants
|
PRIMARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assessing participant intention to use cannabis in the future. Assessed on a Likert-scale (1 - Definitely not, 4 - Definitely yes).
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=127 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=136 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Intention to Use Cannabis in the Future - Smoked Cannabis
Baseline - Ever-Users
|
2.71 score on a scale
Standard Deviation 0.95
|
3.67 score on a scale
Standard Deviation 0.58
|
|
Intention to Use Cannabis in the Future - Smoked Cannabis
Post-intervention (approx. 3 days post-baseline) - Ever-Users
|
2.57 score on a scale
Standard Deviation 1.13
|
2.44 score on a scale
Standard Deviation 1.42
|
|
Intention to Use Cannabis in the Future - Smoked Cannabis
6-month Follow-up - Ever-Users
|
3.08 score on a scale
Standard Deviation 0.52
|
3.58 score on a scale
Standard Deviation 0.67
|
|
Intention to Use Cannabis in the Future - Smoked Cannabis
Baseline - Never-Users
|
1.85 score on a scale
Standard Deviation 0.95
|
1.92 score on a scale
Standard Deviation 0.99
|
|
Intention to Use Cannabis in the Future - Smoked Cannabis
Post-intervention (approx. 3 days post-baseline) - Never-Users
|
1.78 score on a scale
Standard Deviation 0.92
|
1.85 score on a scale
Standard Deviation 0.95
|
|
Intention to Use Cannabis in the Future - Smoked Cannabis
6-month Follow-up - Never-Users
|
1.92 score on a scale
Standard Deviation 0.95
|
1.88 score on a scale
Standard Deviation 1.0
|
PRIMARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assessing participant intention to use cannabis in the future. Assessed on a Likert-scale (1 - Definitely not, 4 - Definitely yes).
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=126 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=136 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Intention to Use Cannabis in the Future - Vaped Cannabis
Baseline - Ever-Users
|
2.67 score on a scale
Standard Deviation 0.87
|
2.6 score on a scale
Standard Deviation 1.34
|
|
Intention to Use Cannabis in the Future - Vaped Cannabis
Post-intervention (approx. 3 days post-baseline) - Ever-Users
|
2.7 score on a scale
Standard Deviation 0.95
|
2.4 score on a scale
Standard Deviation 1.35
|
|
Intention to Use Cannabis in the Future - Vaped Cannabis
6-month Follow-up - Ever-Users
|
2.75 score on a scale
Standard Deviation 1.04
|
2.94 score on a scale
Standard Deviation 1.06
|
|
Intention to Use Cannabis in the Future - Vaped Cannabis
Baseline - Never-Users
|
1.46 score on a scale
Standard Deviation 0.65
|
1.61 score on a scale
Standard Deviation 0.73
|
|
Intention to Use Cannabis in the Future - Vaped Cannabis
Post-intervention (approx. 3 days post-baseline) - Never-Users
|
1.43 score on a scale
Standard Deviation 0.68
|
1.56 score on a scale
Standard Deviation 0.71
|
|
Intention to Use Cannabis in the Future - Vaped Cannabis
6-month Follow-up - Never-Users
|
1.5 score on a scale
Standard Deviation 0.74
|
1.56 score on a scale
Standard Deviation 0.73
|
PRIMARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assessing participant intention to use cannabis in the future. Assessed on a Likert-scale (1 - Definitely not, 4 - Definitely yes).
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=126 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=136 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Intention to Use Cannabis in the Future - Cannabis Edibles
Baseline - Ever-Users
|
2.71 score on a scale
Standard Deviation 0.95
|
2.86 score on a scale
Standard Deviation 0.9
|
|
Intention to Use Cannabis in the Future - Cannabis Edibles
Post-intervention (approx. 3 days post-baseline) - Ever-Users
|
2.5 score on a scale
Standard Deviation 1.07
|
2.45 score on a scale
Standard Deviation 1.29
|
|
Intention to Use Cannabis in the Future - Cannabis Edibles
6-month Follow-up - Ever-Users
|
3.0 score on a scale
Standard Deviation 1.0
|
3.45 score on a scale
Standard Deviation 0.69
|
|
Intention to Use Cannabis in the Future - Cannabis Edibles
Baseline - Never-Users
|
1.88 score on a scale
Standard Deviation 0.95
|
1.88 score on a scale
Standard Deviation 0.95
|
|
Intention to Use Cannabis in the Future - Cannabis Edibles
Post-intervention (approx. 3 days post-baseline) - Never-Users
|
1.83 score on a scale
Standard Deviation 0.95
|
1.95 score on a scale
Standard Deviation 0.99
|
|
Intention to Use Cannabis in the Future - Cannabis Edibles
6-month Follow-up - Never-Users
|
1.89 score on a scale
Standard Deviation 0.81
|
1.97 score on a scale
Standard Deviation 1.04
|
SECONDARY outcome
Timeframe: Baseline and Post-intervention (approx. 3 days post-baseline)Population: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Participants were asked 13 questions related to their knowledge of cannabis, resulting in an overall scale of 0 to 13, higher scores indicated greater knowledge.
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=128 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=137 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Cannabis Knowledge
Baseline
|
6.45 score on a scale
Standard Deviation 2.21
|
6.28 score on a scale
Standard Deviation 1.98
|
|
Cannabis Knowledge
Post-intervention (approx. 3 days post-baseline)
|
7.64 score on a scale
Standard Deviation 2.84
|
6.20 score on a scale
Standard Deviation 2.49
|
SECONDARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assessing participants' perceptions of cannabis addiction and harm. Assessed on a Likert-scale (1 - Not at all addictive/harmful, 5 - Extremely addictive/harmful).
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=128 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=137 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Perceived Addictiveness and Harmfulness - Smoked Cannabis
Baseline - Addictiveness
|
3.78 score on a scale
Standard Deviation 1.04
|
3.59 score on a scale
Standard Deviation 1.01
|
|
Perceived Addictiveness and Harmfulness - Smoked Cannabis
Post-intervention (approx. 3 days post-baseline) - Addictiveness
|
3.98 score on a scale
Standard Deviation 1.04
|
3.69 score on a scale
Standard Deviation 1.03
|
|
Perceived Addictiveness and Harmfulness - Smoked Cannabis
6-month Follow-up - Addictiveness
|
3.59 score on a scale
Standard Deviation 1.09
|
3.4 score on a scale
Standard Deviation 1.08
|
|
Perceived Addictiveness and Harmfulness - Smoked Cannabis
Baseline - Harmfulness
|
3.85 score on a scale
Standard Deviation 1.04
|
3.95 score on a scale
Standard Deviation 0.97
|
|
Perceived Addictiveness and Harmfulness - Smoked Cannabis
Post-intervention (approx. 3 days post-baseline) - Harmfulness
|
4.2 score on a scale
Standard Deviation 0.95
|
3.99 score on a scale
Standard Deviation 0.96
|
|
Perceived Addictiveness and Harmfulness - Smoked Cannabis
6-month Follow-up - Harmfulness
|
3.86 score on a scale
Standard Deviation 1.04
|
3.81 score on a scale
Standard Deviation 1.04
|
SECONDARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assessing participants' perceptions of cannabis addiction and harm. Assessed on a Likert-scale (1 - Not at all addictive/harmful, 5 - Extremely addictive/harmful).
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=128 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=137 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Perceived Addictiveness and Harmfulness - Vaped Cannabis
Baseline - Addictiveness
|
4.36 score on a scale
Standard Deviation 0.97
|
4.21 score on a scale
Standard Deviation 0.93
|
|
Perceived Addictiveness and Harmfulness - Vaped Cannabis
Post-intervention (approx. 3 days post-baseline) - Addictiveness
|
4.38 score on a scale
Standard Deviation 0.99
|
4.17 score on a scale
Standard Deviation 1.02
|
|
Perceived Addictiveness and Harmfulness - Vaped Cannabis
6-month Follow-up - Addictiveness
|
4.23 score on a scale
Standard Deviation 1.0
|
4.0 score on a scale
Standard Deviation 1.11
|
|
Perceived Addictiveness and Harmfulness - Vaped Cannabis
Baseline - Harmfulness
|
4.23 score on a scale
Standard Deviation 0.83
|
4.13 score on a scale
Standard Deviation 0.9
|
|
Perceived Addictiveness and Harmfulness - Vaped Cannabis
Post-intervention (approx. 3 days post-baseline) - Harmfulness
|
4.53 score on a scale
Standard Deviation 0.73
|
4.12 score on a scale
Standard Deviation 0.95
|
|
Perceived Addictiveness and Harmfulness - Vaped Cannabis
6-month Follow-up - Harmfulness
|
4.19 score on a scale
Standard Deviation 0.83
|
4.07 score on a scale
Standard Deviation 0.93
|
SECONDARY outcome
Timeframe: Baseline, Post-intervention (approx. 3 days post-baseline), and 6-month Follow-upPopulation: Students from middle schools who received the allocated intervention and responded to the survey at the respective time points.
Investigator-originated survey measures (questions) assessing participants' perceptions of cannabis addiction and harm. Assessed on a Likert-scale (1 - Not at all addictive/harmful, 5 - Extremely addictive/harmful).
Outcome measures
| Measure |
Receives the Stanford Cannabis Prevention and Awareness Curriculum
n=128 Participants
Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
|
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
n=136 Participants
Receives another curriculum or no cannabis prevention curriculum
|
|---|---|---|
|
Perceived Addictiveness and Harmfulness - Cannabis Edibles
Baseline - Addictiveness
|
3.43 score on a scale
Standard Deviation 1.15
|
3.41 score on a scale
Standard Deviation 1.01
|
|
Perceived Addictiveness and Harmfulness - Cannabis Edibles
Post-intervention (approx. 3 days post-baseline) - Addictiveness
|
3.73 score on a scale
Standard Deviation 1.13
|
3.41 score on a scale
Standard Deviation 1.15
|
|
Perceived Addictiveness and Harmfulness - Cannabis Edibles
6-month Follow-up - Addictiveness
|
3.25 score on a scale
Standard Deviation 1.16
|
3.09 score on a scale
Standard Deviation 1.09
|
|
Perceived Addictiveness and Harmfulness - Cannabis Edibles
Baseline - Harmfulness
|
3.36 score on a scale
Standard Deviation 1.13
|
3.47 score on a scale
Standard Deviation 1.14
|
|
Perceived Addictiveness and Harmfulness - Cannabis Edibles
Post-intervention (approx. 3 days post-baseline) - Harmfulness
|
3.78 score on a scale
Standard Deviation 1.06
|
3.39 score on a scale
Standard Deviation 1.19
|
|
Perceived Addictiveness and Harmfulness - Cannabis Edibles
6-month Follow-up - Harmfulness
|
3.41 score on a scale
Standard Deviation 1.14
|
3.17 score on a scale
Standard Deviation 1.2
|
Adverse Events
Receives the Stanford Cannabis Prevention and Awareness Curriculum
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Does Not Receive Stanford Cannabis Prevention and Awareness Curriculum
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place