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Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder

NCT05517304 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-03-03

No results posted yet for this study

Summary

This study effects the effects of transcutaneous cervical vagal nerve stimulation (tcVNS) or a sham control on brain, physiology, and PTSD symptoms in Veterans with posttraumatic stress disorder (PTSD). Veterans undergo brain imaging and physiological measures in conjunction with traumatic scripts before and after three months of twice daily treatment with tcVNS or sham stimulation at home.

Conditions

  • Stress Disorders, Post-Traumatic

Interventions

DEVICE

tcVNS

Active stimulation with transcutaneous Vagal Nerve Stimulation (tcVNS)

DEVICE

Sham

Sham stimulation

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Doug J Bremner, MD · Atlanta VA Medical and Rehab Center, Decatur, GA

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-01
Primary Completion
2027-07-08
Completion
2027-11-10
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05517304 on ClinicalTrials.gov