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Ultrasonic Deep Brain Stimulation During Anesthetic Sedation

NCT05495945 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 13

Last updated 2025-03-12

Study results available
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Summary

The purpose of this study is to see if mental functions take place during different levels of anesthesia. The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia, and to evaluate if the use of ultrasonic brain stimulation accelerates return to consciousness.

Conditions

  • Mental Function

Interventions

DEVICE

Low-intensity focused ultrasound pulsation (LIFUP)

LIFUP will be used to stimulate specific brain regions and assess their causal involvement in the control of conscious state and contents.

COMBINATION_PRODUCT

Functional Magnetic Resonance Imaging (fMRI) using Propofol

Propofol will be administered by intravenous infusion. All anesthesia equipment, supplies, and drugs will be provided by anesthesiologists from the University of Michigan Health System. The researchers will manually control the infusion of propofol to achieve target effect-site concentrations

Sponsors & Collaborators

Principal Investigators

  • Zirui Huang · University of Michigan

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-26
Primary Completion
2023-10-07
Completion
2023-10-07
FDA Drug
Yes
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05495945 on ClinicalTrials.gov