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Test Retest Reliability of OA and OH

NCT05487183 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 74

Last updated 2024-06-20

No results posted yet for this study

Summary

The goal of this study is to measure the test retest reliability of offset analgesia (OA) and onset hyperalgesia (OH) across multiple study visits. OA and OH are quantitative sensory tests (QST) thought to measure how the brain modulates pain. This study will use a heat thermode to induce OA and OH in healthy, pain-free volunteers across 3 study visits. Additional QST measures and survey data relevant to pain modulation will be collected. This study lays the foundation required to use OA and OH as tools to measure pain modulation in clinical trials. Following their validation, we anticipate that OA and OH will serve as predictive and therapeutic biomarkers, which will aid both in the development of novel analgesics and in treatment selection leading to the personalization of pain management.

Conditions

  • Analgesia
  • Pain Catastrophizing
  • Pain

Interventions

BEHAVIORAL

Medoc cutaneous probe

A computer-controlled probe delivers temperatures to the skin to measure pain, OA, and OH

BEHAVIORAL

Quantitative sensory testing

Standard methods involving pinprick, pressure, heat, and cold applied to the skin are used to measure sensation and pain

BEHAVIORAL

Computer tasks

QST and computer tasks are used to measure changes in pain intensity

Sponsors & Collaborators

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Benedict Alter, MD, PhD · University of Pittsburgh

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-05
Primary Completion
2024-04-10
Completion
2024-04-10

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05487183 on ClinicalTrials.gov