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Efficacy of Duloxetine Compared to NSIADs in Osteoarthritis of Knee

NCT05486026 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2023-03-14

No results posted yet for this study

Summary

Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 25% of the population . Knee OA is an insidious disease related to structural changes in the joint over many years. Progressive articular damage results in a loss of the extracellular matrix of cartilage in addition to changes in subchondral bone.

Duloxetine, a selective serotonin, and norepinephrine reuptake inhibitor, it seems to be effective in treating neuropathic and chronic pain conditions.

Conditions

  • Osteo Arthritis Knee

Interventions

DRUG

Duloxetine 30 MG

patient in first group (case) will receive duloxetine tablet 30mg for two weeks then titrated up to duloxetine 30mg BID. Patients will be instructed to take the medication with meals. The for 13 weeks

DRUG

Nonsteroidal Antiinflammatory Drug

patient in this second group will receive NSAID for 3 weeks

Sponsors & Collaborators

  • Hawler Medical University

    lead OTHER

Principal Investigators

  • Aryan MF jalal, M.B.CH.B · Rheumatology , Hawler Medical University, Kurdistan Board for medical specialties

  • Niaz Albarzinji, MBCHB,DRMR · Rheumatology, Hawler medical university/college of medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-20
Primary Completion
2022-12-29
Completion
2023-01-02

Countries

  • Iraq

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05486026 on ClinicalTrials.gov