MedTrace Logo

Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans

NCT05480943 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 206

Last updated 2026-08-12

Study results available
· View outcomes & findings →

Summary

Thiamine micronutrient deficiency (TD) can cause a variety of non-specific symptoms and leads to several thiamine deficiency disorders such as heart failure, polyneuropathy, Wernicke's Encephalopathy and generalized weakness and debility. Symptoms are often vague and non-specific such as fatigue, leg swelling, imbalance, confusion, mood disorders, gastrointestinal upset, and weakness. Hospitalized Veterans may be particularly susceptible to TD due to food insecurity and chronic illnesses which cause inflammation and increased metabolic demands. This study aims to determine the prevalence of TD in hospitalized Veterans which has never been done before. The investigators also seek to identify risk factors causing TD including acute and chronic forms of inflammation, food insecurity, and dietary habits. Lastly, the investigators hope to clarify the abnormally low levels of blood thiamine that correlate with symptoms of TD that improve with replenishment.

Conditions

  • Thiamine Deficiency
  • Thiamine Deficiency; Sequelae

Interventions

DIETARY_SUPPLEMENT

Thiamine repletion

If a participant is determined by clinical characteristics or biomarker results to be thiamine deficient, thiamine supplementation was provided.

Sponsors & Collaborators

  • VA Sierra Nevada Health Care System

    collaborator FED

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Elisabeth A Mates, MD PhD · VA Sierra Nevada Health Care System, Reno, NV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-07-19
Primary Completion
2024-09-30
Completion
2024-12-30

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05480943 on ClinicalTrials.gov