Study on the Correlation Between Neurotrophic Factors and the Condition of Stroke Patients

Summary

Stroke is currently the most common disabling disease, which often leads to impairment of sensory, motor, speech and psychological functions, resulting in a reduced quality of life for patients. Therefore, post-stroke functional rehabilitation, especially the rehabilitation of physical function and psychological condition, is particularly important for patients to rejoin society. Acupuncture can promote the functional recovery of patients and facilitate the rehabilitation of limb function, thus improving the quality of survival of post-stroke patients.

Neurotrophic factors are diverse, most of which are mainly derived from neuronal cells in the central nervous system and are involved in a variety of neurological functions such as cell growth, differentiation and plasticity, thus promoting recovery of multiple functions after stroke. Many studies have found that different interventions affect the prognosis of stroke patients differently, e.g., long-term acupuncture increases serum levels of brain-derived neurotrophic factor in stroke patients and also has better outcomes than controls in post-stroke neurological recovery and the development of post-stroke psychiatric disorders.

This study investigated the effects of different therapeutic measures on patients' functional recovery and neurotrophic factors by setting up a controlled and blinded trial design, which could not only provide clinical evidence for the effectiveness of relevant therapeutic measures, but also verify the clinical value of certain neurotrophic factors (e.g., predicting outcome, assessing condition, and preventing adverse events).

Conditions

• Stroke

Interventions

PROCEDURE

acupuncture

Manual acupuncture or electro-acupuncture by experienced acupuncturists for patients

BEHAVIORAL

computerized cognitive training system

One-on-one cognitive training by an experienced cognitive therapist, combined with an existing computerized cognitive training system

BEHAVIORAL

aerobic exercise

Patients are trained by experienced physical therapists with the help of elastic bands and physical therapy devices

BEHAVIORAL

tranditional cognitive training

One-on-one cognitive training with an experienced cognitive therapist, combined with traditional cognitive training methods (e.g., balls, cards, counting, daily conversation, etc.)

OTHER

Conventional treatment

Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation

Sponsors & Collaborators

• Chongqing Medical University

  lead OTHER

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-11-16

Primary Completion

2024-12-31

Completion

2024-12-31

Countries

• China

Study Locations