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Intraoperative Sonographically Versus Fluorescence-guided Resection of Contrast-enhancing Gliomas and Brain Metastases

NCT05475522 · Status: SUSPENDED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 134

Last updated 2025-05-16

No results posted yet for this study

Summary

Objective of the study is to determine whether intraoperative ultrasound guided resection of gliomas with contrast enhancement in magnetic resonance imaging and brain metastases can achieve as high rate of gross total resection as fluorescence-guided surgery with 5-aminolevulinic acid

Conditions

  • Gliomas, Malignant
  • Metastases to Brain

Interventions

DEVICE

Ultrasound guided brain tumor resection

Surgeon intraoperatively assesses extent of tumor resection using ultrasound

DEVICE

5-aminolevulinic acid fluorescence-guided brain tumor resection

Surgeon intraoperatively assesses extent of tumor resection observing it's fluorescence in microscope

Sponsors & Collaborators

  • Sklifosovsky Institute of Emergency Care

    lead OTHER_GOV

Principal Investigators

  • Alexander Dmitriev, MD · Sklifosovsky Institute of Emergency Care

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-01
Primary Completion
2027-08-31
Completion
2027-08-31

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05475522 on ClinicalTrials.gov