Trial Outcomes & Findings for Impact of 2 Resuscitation Sequences on Management of Simulated Pediatric Cardiac Arrest (NCT NCT05474170)
NCT ID: NCT05474170
Last Updated: 2026-04-03
Results Overview
The alveolar ventilation was determined by subtracting the dead space volume from each ventilation. According to the appropriate Best Guess formula, a 9-month old infant should weigh around 9 kg (0.5 x age in months + 4.5). Using the formula proposed by Numa and Newth, this corresponds to a dead space of around 25 ml. The value reported was the median \[quartiles\] over the first minute.
COMPLETED
NA
28 participants
1 minute
2026-04-03
Participant Flow
Participant milestones
| Measure |
AHA --> ERC
This group will first apply the AHA resuscitation sequence, then the ERC one
|
ERC --> AHA
This group will first apply the ERC resuscitation sequence, then the AHA one
|
|---|---|---|
|
Overall Study
STARTED
|
14
|
14
|
|
Overall Study
COMPLETED
|
14
|
14
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Overall Participants
n=28 Participants
Participants were randomized using a cross-over design, such that all participants performed both resuscitation approaches: the ventilation-first sequence and the compression-first sequence. Because each participant served as their own control, baseline characteristics were identical for both intervention sequences. Consequently, participant characteristics were summarized once in a single table, rather than separately by study arm, as reported in the published manuscript. This approach is consistent with the cross-over study design and reflects the methods and reporting used in the final publication.
|
|---|---|
|
Age, Continuous
|
32 Years
n=28 Participants
|
|
Sex/Gender, Customized
Gender · Woman
|
19 Participants
n=28 Participants
|
|
Sex/Gender, Customized
Gender · Man
|
9 Participants
n=28 Participants
|
PRIMARY outcome
Timeframe: 1 minutePopulation: Considering that a total of 28 participants registered, and related to the cross-over design, 56 resuscitation sequences were recorded and analyzed.
The alveolar ventilation was determined by subtracting the dead space volume from each ventilation. According to the appropriate Best Guess formula, a 9-month old infant should weigh around 9 kg (0.5 x age in months + 4.5). Using the formula proposed by Numa and Newth, this corresponds to a dead space of around 25 ml. The value reported was the median \[quartiles\] over the first minute.
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
Median Alveolar Ventilation
|
370 ml
Interval 203.0 to 472.0
|
276 ml
Interval 140.0 to 360.0
|
SECONDARY outcome
Timeframe: 1 minuteThis will be the count of the number of ventilations delivered during the one-minute scenario
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
The Total Number of Ventilations
|
13 Ventilations
Interval 12.0 to 15.0
|
10 Ventilations
Interval 8.0 to 10.0
|
SECONDARY outcome
Timeframe: 1 minuteAccording to the manikin's manufacturer, the target is 30 to 70 ml. \>70 ml was considered "Above" and \<30 ml was considered below.
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
The Percentage of Ventilations Within, Above and Below the Target Volume
Below target (<30ml)
|
4 Percentage of ventilations
Interval 0.0 to 23.0
|
0 Percentage of ventilations
Interval 0.0 to 11.0
|
|
The Percentage of Ventilations Within, Above and Below the Target Volume
In target (30-70 ml)
|
76 Percentage of ventilations
Interval 65.0 to 82.0
|
75 Percentage of ventilations
Interval 52.0 to 100.0
|
|
The Percentage of Ventilations Within, Above and Below the Target Volume
Above target (>70 ml)
|
3 Percentage of ventilations
Interval 0.0 to 24.0
|
0 Percentage of ventilations
Interval 0.0 to 31.0
|
SECONDARY outcome
Timeframe: 1 minuteThis is similar to the primary outcome, but for this analysis, all ventilations were individually capped at 70 ml. The value reported was the median \[quartiles\] over the first minute.
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
The Alveolar Ventilation Obtained Without Taking Ventilation Volumes Over 70 ml Into Account, Reported as the Median Value of the Ventilations Over the First Minute.
|
365 ml
Interval 203.0 to 445.0
|
271 ml
Interval 138.0 to 353.0
|
SECONDARY outcome
Timeframe: 1 minuteThe chest compression were considered correct if ≥ 4.3 cm, corresponding to one third of the height of the manikin's chest i.e., 13 cm). A second target of 3 cm or more was also reported.
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
The Percentage of Compressions of Correct Depth
According to the manikin's size (4.3 cm or more)
|
0 Percentage of correct depth compressions
Interval 0.0 to 0.0
|
0 Percentage of correct depth compressions
Interval 0.0 to 0.0
|
|
The Percentage of Compressions of Correct Depth
According to the target 3 cm or more
|
91 Percentage of correct depth compressions
Interval 17.0 to 100.0
|
89 Percentage of correct depth compressions
Interval 36.0 to 99.0
|
SECONDARY outcome
Timeframe: 1 minuteAccording to the guidelines, the target is 100 to 120 compressions per minute
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
The Percentage of Chest Compressions Within, Above and Below the Target Rate.
Below target (<100 cpm)
|
0 Percentage of correct compressions
Interval 0.0 to 20.0
|
3 Percentage of correct compressions
Interval 0.0 to 13.0
|
|
The Percentage of Chest Compressions Within, Above and Below the Target Rate.
Above target (>120 cpm)
|
1 Percentage of correct compressions
Interval 0.0 to 7.0
|
0 Percentage of correct compressions
Interval 0.0 to 9.0
|
|
The Percentage of Chest Compressions Within, Above and Below the Target Rate.
In target (100-120 cpm)
|
91 Percentage of correct compressions
Interval 57.0 to 98.0
|
90 Percentage of correct compressions
Interval 55.0 to 96.0
|
SECONDARY outcome
Timeframe: 1 minuteThis corresponds to the time with compressions on the total time of the cardiopulmonary resuscitation sequence
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
The Chest Compression Fraction (CCF)
|
57 Percentage of time
Interval 54.0 to 64.0
|
66 Percentage of time
Interval 59.0 to 68.0
|
SECONDARY outcome
Timeframe: 1 minuteThis corresponds to the proportion of compressions enough relaxed to let complete heart relaxation
Outcome measures
| Measure |
ERC Approach (Ventilation-first)
n=28 Participants
This group apply the ERC resuscitation sequence (ventilation-first) with 5 initial rescue breaths.
|
AHA Approach (Compression-first)
n=28 Participants
This group apply the AHA resuscitation sequence (compression-first).
|
|---|---|---|
|
The Percentage of Compressions With Adequate Chest Recoil
|
93 Percentage of correct compressions
Interval 42.0 to 100.0
|
76 Percentage of correct compressions
Interval 34.0 to 92.0
|
Adverse Events
AHA Approach (Compression-first)
ERC Approach (Ventilation-first)
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place