SWITCH ON: Analysing the Immunogenicity of Additional Booster Vaccinations in HCW

Summary

Eighty percent of the Dutch population has completed a primary COVID-19 vaccination regimen, and 60% of the population received a booster vaccination. Waning immunity, combined with the emergence of antigenically distinct SARS-CoV-2 variants, has led to the consideration of additional booster vaccinations in the Dutch population by autumn 2022. However, despite efforts of the Dutch policymakers, the public's willingness to repeatedly receive COVID-19 booster vaccinations is declining. This is mainly due to a reduced burden of disease by COVID-19, fewer hospitalizations, and fewer deaths. However, population immunity might be one of the major factors responsible for this reduced burden of disease, possibly emphasizing the need for booster vaccinations. In this proposal we will address an important question asked by policymakers: "Are booster vaccinations in autumn recommended for the healthy population?"

Conditions

• Covid-19 Vaccination

Interventions

DRUG

Direct boost mRNA

Participants will be boosted with a covid-19 vaccin after priming with mRNA

DRUG

Direct boost adeno

Participants will be boosted with a covid-19 vaccin after priming with adeno

DRUG

Post-poned boost mRNA

Participants will be boosted with a covid-19 vaccin after priming with mRNA

DRUG

Post-poned boost adeno

Participants will be boosted with a covid-19 vaccin after priming with adeno

Sponsors & Collaborators

• ZonMw: The Netherlands Organisation for Health Research and Development

  collaborator OTHER

• Leiden University Medical Center

  collaborator OTHER

• University Medical Center Groningen

  collaborator OTHER

• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

  collaborator OTHER

• Erasmus Medical Center

  lead OTHER

Principal Investigators

• Hugo van der Kuy, PharmD · Erasmus MC, Rotterdam

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

67 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-08-20

Primary Completion

2022-09-15

Completion

2023-08-30

Countries

• Netherlands

Study Locations